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BLAHUTA, Jiří, Tomáš SOUKUP and Lukáš PAVLÍK. The Black-White Pixels Ratio in Medial Temporal Lobe Brain Structure in Transcranial B-Images as a Measurable Marker of Alzheimer’s Disease Probability: The Reproducibility Overview. Online. In 2020 International Conference on Software, Telecommunications and Computer Networks (SoftCOM). Split, Croatia: IEEE, 2020, p. 1-6, 7 pp. ISBN 978-1-7281-7538-6. Available from: https://dx.doi.org/10.23919/SoftCOM50211.2020.9238214.

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TY  - JOUR
ID  - 5107
AU  - Blahuta, Jiří - Soukup, Tomáš - Pavlík, Lukáš
PY  - 2020
TI  - The Black-White Pixels Ratio in Medial Temporal Lobe Brain Structure in Transcranial B-Images as a Measurable Marker of Alzheimer’s Disease Probability: The Reproducibility Overview
PB  - IEEE
CY  - Split, Croatia
SN  - 9781728175386
KW  - medial temporal lobe echogenicity
KW  - B-image echogenicity
KW  - Alzheimer’s Disease
KW  - MTL atrophy
KW  - black-white ratio
N2  - The objective of the presented study is to introduce analysis the black-white pixels ratio in medial temporal lobe (MTL) brain structure in digitized transcranial B-images using our developed software B-MODE Assist. This ratio could be a significant marker related to the echogenicity grade. In B-image, the MTL is stable anechogenic structure but increased echogenicity of surrounding cortex is detectable in the case of MTL atrophy; the atrophy predicts Alzheimer’s Disease. Within this study, a set of 97 B-images is used. There are two key goals of this pilot study; verify the reproducibility of the ratio between two observers and to show that the ratio is not much different in the case of original image in comparison with a magnified segment and using constant brightness increasing; the ratio should be independent on image resolution and brightness. To select medial temporal lobe structure, a 20mm square-shaped Region of Interest is used. The correlation coefficient r=0.69 was achieved between two independent, non-experienced observers. The error does not exceed 28 % between 2 non-experienced observers and does not exceed 12 % between the measurements from the same observer. Also, the variance and the range were computed. Achieved results have been judged by an experienced sonographer. In the future, the ratio could be an effective value to determine the MTL atrophy based on the ratio value and possibility to create a rule-based expert system which should help evaluate probability of Alzheimer’s Disease based on the cortex echogenicity grade. In general, this approach could be a reliable way to detect risk of Alzheimer’s Disease using neurosonological imaging.
ER  -

Basic information
Original name	The Black-White Pixels Ratio in Medial Temporal Lobe Brain Structure in Transcranial B-Images as a Measurable Marker of Alzheimer’s Disease Probability: The Reproducibility Overview
Authors	BLAHUTA, Jiří (203 Czech Republic, belonging to the institution), Tomáš SOUKUP (203 Czech Republic) and Lukáš PAVLÍK (203 Czech Republic, belonging to the institution).
Edition	Split, Croatia, 2020 International Conference on Software, Telecommunications and Computer Networks (SoftCOM), p. 1-6, 7 pp. 2020.
Publisher	IEEE

Other information
Original language	English
Type of outcome	Proceedings paper
Field of Study	10201 Computer sciences, information science, bioinformatics
Confidentiality degree	is not subject to a state or trade secret
Publication form	electronic version available online
RIV identification code	RIV/26867184:_____/20:N0000023
Organization unit	Moravian Business College Olomouc
ISBN	978-1-7281-7538-6
Doi	http://dx.doi.org/10.23919/SoftCOM50211.2020.9238214
Keywords in English	medial temporal lobe echogenicity; B-image echogenicity; Alzheimer’s Disease; MTL atrophy; black-white ratio
Tags	RIV20
Changed by	Changed by: Ing. Michaela Nováková, učo 5293. Changed: 4/5/2021 09:25.

Abstract
The objective of the presented study is to introduce analysis the black-white pixels ratio in medial temporal lobe (MTL) brain structure in digitized transcranial B-images using our developed software B-MODE Assist. This ratio could be a significant marker related to the echogenicity grade. In B-image, the MTL is stable anechogenic structure but increased echogenicity of surrounding cortex is detectable in the case of MTL atrophy; the atrophy predicts Alzheimer’s Disease. Within this study, a set of 97 B-images is used. There are two key goals of this pilot study; verify the reproducibility of the ratio between two observers and to show that the ratio is not much different in the case of original image in comparison with a magnified segment and using constant brightness increasing; the ratio should be independent on image resolution and brightness. To select medial temporal lobe structure, a 20mm square-shaped Region of Interest is used. The correlation coefficient r=0.69 was achieved between two independent, non-experienced observers. The error does not exceed 28 % between 2 non-experienced observers and does not exceed 12 % between the measurements from the same observer. Also, the variance and the range were computed. Achieved results have been judged by an experienced sonographer. In the future, the ratio could be an effective value to determine the MTL atrophy based on the ratio value and possibility to create a rule-based expert system which should help evaluate probability of Alzheimer’s Disease based on the cortex echogenicity grade. In general, this approach could be a reliable way to detect risk of Alzheimer’s Disease using neurosonological imaging.

Abstract

The objective of the presented study is to introduce analysis the black-white pixels ratio in medial temporal lobe (MTL) brain structure in digitized transcranial B-images using our developed software B-MODE Assist. This ratio could be a significant marker related to the echogenicity grade. In B-image, the MTL is stable anechogenic structure but increased echogenicity of surrounding cortex is detectable in the case of MTL atrophy; the atrophy predicts Alzheimer’s Disease. Within this study, a set of 97 B-images is used. There are two key goals of this pilot study; verify the reproducibility of the ratio between two observers and to show that the ratio is not much different in the case of original image in comparison with a magnified segment and using constant brightness increasing; the ratio should be independent on image resolution and brightness. To select medial temporal lobe structure, a 20mm square-shaped Region of Interest is used. The correlation coefficient r=0.69 was achieved between two independent, non-experienced observers. The error does not exceed 28 % between 2 non-experienced observers and does not exceed 12 % between the measurements from the same observer. Also, the variance and the range were computed. Achieved results have been judged by an experienced sonographer. In the future, the ratio could be an effective value to determine the MTL atrophy based on the ratio value and possibility to create a rule-based expert system which should help evaluate probability of Alzheimer’s Disease based on the cortex echogenicity grade. In general, this approach could be a reliable way to detect risk of Alzheimer’s Disease using neurosonological imaging.