There are no official statistics in the Czech Republic and Poland mapping the number of start-ups, spin-offs, and organizations supporting innovative businesses. The paper defines the specifics of innovation ecosystem in selected regions of the CZ Moravian-Silesian Region and PL Silesian Voivodeship. Similar economic and socio-cultural developments characterize chosen regions. Hypotheses are defined whose statistical significance is evaluated through the Pearson Chi-Square test. The results are estimated separately for the Moravian-Silesian Region and Silesian Voivodeship and focus on identifying the ownership of organizations, the nature of services provided, and the average annual occupancy of clients in the business phase financing business support programs and possible cooperation between organization. Using the hierarchical cluster analysis with the Ward method, the authors described four clusters. Based on the results obtained from the solution, a general model of the innovation ecosystem supporting innovative entrepreneurship is defined.