The world soon ends up the first year of the novel coronavirus SARS-CoV-2, causing a disease labelled as COVID-19. As this disease has been new to everyone, different countries have approached the fight against the disease differently. There is no universal guide on how to deal with the disease’s spread or mitigate its consequences. This chapter introduces and summarises the most important policy measures and strategies taken by the Czech Government to fight the disease and consequent economic issues. The governmental interventions are related and accompanied by regional situations in terms of fundamental COVID-19 indicators (e.g. number of cases, tests ratio, number of hospitalised people) provided by the Czech Ministry of Health. In this chapter, we draw a line between the measures introduced and their effects and present what socio-economic stimuli were applied to support a comeback to a new normal in the country. Although most of the Government’s actions have been nationwide, geographically, we try to focus on regional differences and commonalities as the disease is often of a hotspot nature. Based on our findings, the measures taken by the Government can control the spreading of COVID-19. Still, it is also strongly dependent on several additional factors like sufficient economic support, Government confidence, restrictions explanations and logic, and people’s willingness to follow these regulations.