In recent decades, research into the quality of life has been carried out by scientists and political organizations. This article follows the European Union's call for a multidimensional approach to research into the quality of life. The article puts forward a novel concept for the quality of life, based on key domains and their respective indicators, as described in the available statistical data. Using multidimensional statistical methods, a synthetic quality of life index is constructed on the basis of the defined quality of life indicators, and a typology of European NUTS 2 is proposed. Linking these outputs and the visualisation that identified the main European regions allows us to evaluate living conditions in the context of the quality of life indicators. The results of our study show that the selected data express the differences in the quality of life in European administrative units and reflect the different development of individual areas in the second half of the 20th century.